Background: Schizotypy, or the set of personality traits related to schizophrenia, is considered an endophenotypic manifestation that is more represented in first-degree relatives of patients with schizophrenia than in the general population. The assessment of schizotypy is primarily based on self-reports, and for this reason it presents several limitations. In order to assess schizotypy, this study proposes a diagnostic instrument based on clinical reports. Methods: A sample of 66 subjects, composed of 25 outpatients with schizophrenia, 18 siblings of these patients and 23 healthy controls, was subjected to the personality assessment test SWAP-200 by trained clinical interviewers. To test the hypothesis of the difference between the profiles of the Personality Disorders within the schizophrenia spectrum, a Multivariate Analysis of Variance and subsequent planned comparisons were conducted. Results: Patients with schizophrenia scored higher than both their siblings and the controls on all SWAP-200 scales; their siblings, compared to the healthy controls, showed significant statistical differences, with higher mean scores for paranoid (F-(1,F-63) = 7.02; p = 0.01), schizoid (F-(1,F-63) = 6.56; p = 0.013) and schizotypal (F-(1,F-63) = 6.47; p = 0.013) traits (PD T scores of Cluster A and Q-factor scores for the schizoid scale [F-(1,F-63) = 6.47; p = 0.013]). Conclusions: Consistent with previous data, first-degree relatives of patients with schizophrenia scored higher on schizophrenia-related personality traits than a general population comparison sample. SWAP-200, as an alternative diagnostic instrument to self-report measures, is able to reveal the higher prevalence of schizotypal traits in siblings of patients with schizophrenia, suggesting its possible use as a complementary instrument for the assessment of schizophrenia.
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机译:背景:精神分裂症或与精神分裂症相关的一系列人格特质被认为是一种内表型表现,在精神分裂症患者的一级亲属中比在一般人群中表现更多。精神分裂症的评估主要基于自我报告,因此,它存在一些局限性。为了评估精神分裂症,这项研究提出了一种基于临床报告的诊断仪器。方法:由受过训练的临床访调员对66名受试者(包括25名精神分裂症门诊患者,其中18名兄弟姐妹和23名健康对照)组成的样本进行了人格评估测试SWAP-200。为了检验精神分裂症范围内人格障碍的特征之间差异的假设,进行了方差的多元分析和随后计划的比较。结果:在所有SWAP-200量表上,精神分裂症患者的得分均高于其兄弟姐妹和对照组。与健康对照组相比,他们的兄弟姐妹表现出显着的统计学差异,偏执狂的平均得分更高(F-(1,F-63)= 7.02; p = 0.01),精神分裂症(F-(1,F-63)= 6.56; p = 0.013)和分裂型(F-(1,F-63)= 6.47; p = 0.013)性状(类A量表的簇A的PD T得分和Q因子得分[F-(1,F- 63)= 6.47; p = 0.013]。结论:与以前的数据一致,精神分裂症患者的一级亲属在精神分裂症相关的人格特质方面得分高于一般人群比较样本。 SWAP-200作为自我报告措施的替代诊断工具,能够揭示精神分裂症患者兄弟姐妹中精神分裂症特征的较高患病率,表明其可能用作评估精神分裂症的辅助手段。
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